CLIMIL-COMPLEX

Soy Isoflavones

Soy Isoflavones are bioactive components extracted from soy proteins and are mainly known as daidzein and genistein. They have a structure similar to that of estrogens hence they can mimic their physiological action. They are not harmful as they are able to counteract the uncontrolled proliferation of breast cancer cells due to their ability to reduce sex hormones plasma levels. Comparative studies have shown that premenopausal women under a therapy with isoflavones, (EFSA October 2015) achieved notable improvements in vasomotor symptoms within only three months.

Pueraria Lobata Isoflavones

Pueraria lobata (a.k.a. kudzu) is a native plant of Asia very rich in daidzein and poor in genistein. The intestinal bacterial flora, by transforming daidzein and genistein, produces equol, a substance with an estrogenic activity four times higher than daidzein and twice more powerful than genistein. The presence of Pueraria lobata in the composition of Climil-Complex has many functions: • it enhances estrogenic activity, guaranteeing a greater production of equol, which is the most effective active compound to counteract menopausal symptoms • it allows the absorption of equol even in presence of a non-optimal status of bacterial flora.

Vitex Agnus Castus

It is obtained by the dried ripe fruit of a shrub plant belonging to the family of Verbenaceae. Its use helps to harmonize woman’s hormonal levels by regulating the ovulatory system and improving neurogenerative disorders. The physiotherapeutic action of Agnus Castus is performed at the pituitary gland where it slows down the release of prolactin, giving to the product the characteristics of an oestroprogestin (which does not happen with soy isoflavones only). Furthermore, it acts positively on the regulation of the oestrogen/ progesterone ratio in favor of the latter.

Griffonia Semplicifolia

It is a plant of African origin, rich in 5-hydroxytryptophan (5-HTP), the precursor of serotonin which is involved in improving mood, sleep quality and sleep-wake cycle. In other words, 5-HTP represents an intermediate stage in the metabolism that leads to the synthesis of serotonin, and it is the key that gives access to numerous celebratory activities. In this context, an imbalance of serotonin levels leads to an onset of depressive states.

Monacolin K

It is a metabolite that reflects the chemical structure and pharmacological action of lovastatin and is able to inhibit HMG-CoA reductase, which represents a key enzyme in cholesterol biosynthesis. Furthermore, Monacolin K appears to reduce cardiovascular risk thanks to its anti-arteriosclerotic and vasodilatory effects. If taken in large doses and for long periods it can have the side effects of statins (hepatic changes, muscle toxicity); for this reason the concentration of Monacolina K in Climil-Complex is 5 mg.

Vitamins K1 and D

These vitamins allow the transformation of the protein Osteocalcin in its activated form, which is essential for the fixation of calcium to the bone tissue. It should also be noted that a menopausal woman has a marked decrease in Vitamin K1 levels. Vitamin D, instead, stimulates various calcium transport proteins. The lack of oestrogen during menopause causes the loss of the regulation of the amount of calcium present in the bone tissue (bone metabolism); failing this control, bone calcium is reduced, leading to a porous and fragile structure; in other words: during menopause there is the loss of the balance between osteoblasts (essential for bone formation) and osteoclasts (necessary for bone resorption) as estrogen deficiency causes an increase in osteoclast and physiological aging causes a decrease of osteoblasts.

REFRENCES:

SOY ISOFLAVONES:

–  Kuiper GG, Shughrue PJ, Merchenthaler I, Gustafsson JA (1998) The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems. Front Neuroendocrinol 19:253–286.

–  Zhang X, Shu XO, Li H, Yang G, Li Q, Gao YT, Zheng W (2005) Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 165:1890–1895.

– Koh WP, Wu AH, Wang R, Ang LW, Heng D, Yuan JM, Yu MC (2009) Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study. Am J Epidemiol 170:901–909.

KUDZU and VITEX

• Chen S. N., Friesen J. B., Webster D., Nikolic D., van Breemen R. B., Wang Z. J., et al. (2011). Phytoconstituents from Vitex agnuscastus fruits. Fitoterapia, 82(4), 528– 533. 23.
• Kennedy D. O., Scholey A. B. (2006). The psychopharmacology of European herbs with cognition-enhancing properties. Current Pharmaceutical Design, 12(35), 4613– 4623.
• Makela S. I., Pylkkanen L. H., Santti R. S., Adlercreutz H. (1995). Dietary soybean may be antiestrogenic in male mice. Journal of Nutrition, 125(3), 437– 445.

GRIFFONIA SIMPLICIFOLIA

• Olivier B. Serotonin: a never-ending story. Eur J Pharmacol. 2015;753:2–18. doi: 10.1016/j.ejphar.2014.10.031.

Monakolin K:

• Hong MY, Seeram NP, Zhang Y, et al. Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells. J Nutr Biochem 2008;7:448–58.
• . Heinza T, Schuchardt JP, Möller K, Hadji P, Hahna A. Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. Nut Res 2016;36:1162–1170.