UROSEL

Saw-palmetto

Used in Herbal Medicine to help relieve the urologic symptoms (e.g., weak urine flow/ incomplete voiding/frequent daytime /night time urination) associated with mild to moderate benign prostatic hyperplasia (BPH).

The HMPC (Committee on Herbal Medicinal Products of European Medicince Agency) concluded that saw palmetto fruit (extracted with hexane) can be used to treat the symptoms of benign prostatic hyperplasia (BPH). BPH is a non-cancerous increase in size of the prostate gland which surrounds the urethra, the tube that carries urine from the bladder out of the body.

The HMPC also concluded that, on the basis of its long-standing use, saw palmetto fruit (extracted with ethanol) can be used for the relief of lower urinary tract symptoms (such as difficulty starting urination or a frequent need to urinate) related to BPH, after serious conditions have been excluded by a doctor.

Lycopene

multiple modes of lycopene action in prostate cancer risk reduction were discussed which stressed the inhibition of inflammation, local androgen signaling, multiple levels of antioxidant defense, and reduction of prostate epithelial cell proliferation, all contributing to improving prostate health.

The increased consumption of lycopene containing fruits, vegetables, and especially tomato products, may provide a measure of protection, while complementary therapy with lycopene supplements must await further well-designed clinical trials employing the latest experimental techniques to investigate the most informative physiological indicators.

Selenium

Selenium is of fundamental importance to human health. It is an essential component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defense systems, and immune function. The decline in blood selenium concentration has therefore several potential public health implications, particularly in relation to the chronic disease prevalence of the Western world such as cancer and cardiovascular disease.

selenium most probably has a protective role against development of prostate cancer and its progression to advanced stages. Therefore, selenium supplementation can be proposed for prevention of prostate cancer.

Zinc

Zinc deficiency, cell-mediated immune dysfunction, susceptibility to infections, and increased oxidative stress have been observed in elderly subjects (i.e., those 55-y old). Zinc is an effective anti-inflammatory and antioxidant agent.

After zinc supplementation, the incidence of infections was significantly lower, plasma zinc was significantly higher, and generation of tumor necrosis factor  and oxidative stress markers was significantly lower in the zinc-supplemented than in the placebo group.

Reference

Saw-palmetto

– Health Canada website

– European Medicines Agency, EMA/823974/2015

Lycopene

– Role of lycopene and tomato products in prostate health Maria Stacewicz-SapuntzakisT, Phyllis E. Bowen Department of Human Nutrition, University of Illinois at Chicago, 1919 West Taylor St. Chicago, IL 60612, USA Received 15 September 2004; received in revised form 27 January 2005; accepted 4 February 2005 Available online 13 March 2005.

Selenium

– Selenium, selenoproteins and human health: a review KM Brown1 * and JR Arthur2 1 University of Aberdeen, Scotland: 2 Rowett Research Institute, Aberdeen. Public Health Nutrition: 4(2B), 593±599

– The association between Selenium and Prostate Cancer: a Systematic Review and Meta-Analysis

Kourosh Sayehmiri, Milad Azami, Younes Mohammadi,Ali Soleymani and Zainab Tardeh. Asian Pac J Cancer Prev. 2018; 19(6): 1431–1437.

Zinc

– Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress1–3 Ananda S Prasad, Frances WJ Beck, Bin Bao, James T Fitzgerald, Diane C Snell, Joel D Steinberg, and Lavoisier J Cardozo